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<body class="skin--responsive skin-vector skin-vector-search-vue mediawiki ltr sitedir-ltr mw-hide-empty-elt ns-0 ns-subject page-ATR-Kinase rootpage-ATR-Kinase skin-vector-2022 action-view">
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<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">ATR-Kinase</span></h1>
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<div id="mw-content-text" class="mw-body-content mw-content-ltr" lang="de" dir="ltr"><div class="mw-content-ltr mw-parser-output" lang="de" dir="ltr"><table class="wikitable hintergrundfarbe-basis infobox float-right" id="Vorlage_Infobox_Protein_ATR" style="font-size:90%; margin-top:0; width:350px;" summary="Infobox Protein">
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<th colspan="3" style="background:#90EE90; color:#202122;">ATR
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<td>Andere Namen
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<p>ATR Serine/Threonine Kinase; FRP1; Ataxia Telangiectasia And Rad3-Related Protein; EC 2.7.11.1; FCTCS; SCKL1; MEC1; MEC1, Mitosis Entry Checkpoint 1, Homolog; Ataxia Telangiectasia And Rad3 Related; Serine/Threonine-Protein Kinase ATR; Mitosis Entry Checkpoint 1; Homolog (S. Cerevisiae); FRAP-Related Protein-1; FRAP-Related Protein 1; SCKL
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<th colspan="3" style="background:#90EE90; color:#202122;;">Eigenschaften des menschlichen Proteins
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<td><a href="Molare_Masse" title="Molare Masse">Masse</a>/Länge <a href="Prim%C3%A4rstruktur" title="Primärstruktur">Primärstruktur</a>
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<td colspan="2" style="text-align:center;">2644 Aminosäuren, 301367 Da
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<th colspan="3" style="background:#90EE90; color:#202122;">Bezeichner
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<td>Externe IDs
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<ul><li><a href="GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=ATR">ATR</a></li>
<li><a href="Online_Mendelian_Inheritance_in_Man" title="Online Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/omim/601215">601215</a></li>
<li><a href="UniProt" title="UniProt">UniProt</a> <a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/Q13535">Q13535</a></li></ul>
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<th colspan="3" style="background:#90EE90; color:#202122;">Vorkommen
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<td style="background:#C3FDB8; color:#202122;">Homologie-Familie
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<td colspan="2" style="text-align:center;"><a rel="nofollow" class="external text" href="http://hogenom.univ-lyon1.fr/query_sequence?seq=Q13535">Hovergen</a>
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<td colspan="3" style="background:#90EE90; color:#202122; text-align:center;"><a href="Homologie_(Genetik)#Homologie_zwischen_verdoppelten_oder_fremden_Genen" title="Homologie (Genetik)">Orthologe</a>
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<td style="background:#C3FDB8; color:#202122; text-align:center;">Mensch
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<td style="background:#C3FDB8; color:#202122; text-align:center;">Hausmaus
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<td style="background:#C3FDB8; color:#202122;"><a href="Entrez_Gene" title="Entrez Gene">Entrez</a>
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<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=545&rn=1">545</a></span>
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<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=245000&rn=1">245000</a></span>
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<td style="background:#C3FDB8; color:#202122;"><a href="UniProt" title="UniProt">UniProt</a>
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<td><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/Q13535">Q13535</a>
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<td style="background:#C3FDB8; color:#202122;"><a href="PubMed" title="PubMed">PubMed</a>-Suche
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<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=545">545</a></span>
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<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=245000">245000</a></span>
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</p><p><b>ATR</b> (<i>Ataxia telangiectasia and Rad3 related</i>) ist eine <a href="Proteinkinase" class="mw-redirect" title="Proteinkinase">Proteinkinase</a>, die an der Messung von <a href="DNA-Schaden" title="DNA-Schaden">DNA-Schäden</a> und an <a href="DNA-Reparatur" title="DNA-Reparatur">DNA-Reparatur</a> beteiligt ist.<sup id="cite_ref-DOI10.1016/j.pharmthera.2014.12.001_1-0" class="reference"><a href="#cite_note-DOI10.1016/j.pharmthera.2014.12.001-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>
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<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>
<ol class="references">
<li id="cite_note-DOI10.1016/j.pharmthera.2014.12.001-1"><span class="mw-cite-backlink"><a href="#cite_ref-DOI10.1016/j.pharmthera.2014.12.001_1-0">↑</a></span> <span class="reference-text">Anika Maria Weber, Anderson Joseph Ryan: <i>ATM and ATR as therapeutic targets in cancer.</i> In: <i>Pharmacology & Therapeutics.</i> 149, 2015, S. 124, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1016/j.pharmthera.2014.12.001">10.1016/j.pharmthera.2014.12.001</a></span>. <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/25512053?dopt=Abstract">PMID 25512053</a>.</span>
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Dieser Artikel wurde von <a class="external text" title="Zuletzt bearbeitet am 2024-05-15" href="https://de.wikipedia.org/wiki/?title=ATR-Kinase&oldid=245012788">Wikipedia</a> herausgegeben. Der Text ist unter <a class="external text" href="https://creativecommons.org/licenses/by-sa/4.0/deed.de">Creative Commons Attribution-Share Alike 4.0</a> verfügbar, sofern nicht anders angegeben. Für die Mediendateien können zusätzliche Bedingungen gelten.
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